The research for my PhD is about understanding how chromosome instability impacts ongoing genomic evolution, including differences dependent on the mechanisms of CIN, as well as how these impact the response to therapy. I use High Grade Serous Ovarian Cancer, a cancer that has a extremely high occurrence of chemotherapy resistance and is a highly chromosomally unstable cancer type, as a model to investigate these questions. This includes using in vitro cell biology, syngeneic in vivo models and computational methods to interrogate genomic changes in different CIN environments.