The Chromosomal Instability Lab
(Website under construction - check back in a few days!)
Welcome to our lab website - our common goal is to understand the mechanisms driving chromosomal alterations in cancer cells. We use a range of molecular and cellular biology coupled to single cell genomics tools, and investigate a broad range of cancer types. Most importantly, we have a wonderful lab filled with amazing people - find out more about their projects below!
Dr Audrey Lumeau
Pancreatic Cancer UK post-doctoral fellow
Final year PhD student
PhD student (joint with Dr Susan Cox, Kings College London)
Contain our genetic material
The research for my PhD is about understanding how chromosome instability impacts ongoing genomic evolution, including differences dependent on the mechanisms of CIN, as well as how these impact the response to therapy. I use High Grade Serous Ovarian Cancer, a cancer that has a extremely high occurrence of chemotherapy resistance and is a highly chromosomally unstable cancer type, as a model to investigate these questions. This includes using in vitro cell biology, syngeneic in vivo models and computational methods to interrogate genomic changes in different CIN environments.
News & Events
Research Mechanisms and Data Analysis Techniques: Review
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